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phenobarbital will lower the level or effect of olanzapine/samidorphan by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Robust CYP3A4 inducers lower levels of olanzapine and samidorphan by~fifty% and ~seventy five% respectively.phenobarbital will reduce the extent or outcome of piroxicam by impacting hepatic en